Five new amicoumacins isolated from a marine-derived Bacterium bacillus subtilis

Handle URI:
http://hdl.handle.net/10754/325356
Title:
Five new amicoumacins isolated from a marine-derived Bacterium bacillus subtilis
Authors:
Li, Yongxin; Xu, Ying; Liu, Lingli; Han, Zhuang; Lai, Pok Yui; Guo, Xiangrong; Zhang, Xixiang ( 0000-0002-3478-6414 ) ; Lin, Wenhan; Qian, Pei-Yuan
Abstract:
Four novel amicoumacins, namely lipoamicoumacins A-D (1-4), and one new bacilosarcin analog (5) were isolated from culture broth of a marine-derived bacterium Bacillus subtilis, together with six known amicoumacins. Their structures were elucidated on the basis of extensive spectroscopic (2D NNR, IR, CD and MS) analysis and in comparison with data in literature. 2012 by the authors; licensee MDPI.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; KAUST Global Collaborative Research Program; Advanced Nanofabrication, Imaging and Characterization Core Lab
Citation:
Li Y, Xu Y, Liu L, Han Z, Lai PY, et al. (2012) Five New Amicoumacins Isolated from a Marine-Derived Bacterium Bacillus subtilis. Marine Drugs 10: 319-328. doi:10.3390/md10020319.
Publisher:
MDPI AG
Journal:
Marine Drugs
Issue Date:
3-Feb-2012
DOI:
10.3390/md10020319
PubMed ID:
22412803
PubMed Central ID:
PMC3296999
Type:
Article
ISSN:
16603397
Appears in Collections:
Articles; Advanced Nanofabrication, Imaging and Characterization Core Lab; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorLi, Yongxinen
dc.contributor.authorXu, Yingen
dc.contributor.authorLiu, Linglien
dc.contributor.authorHan, Zhuangen
dc.contributor.authorLai, Pok Yuien
dc.contributor.authorGuo, Xiangrongen
dc.contributor.authorZhang, Xixiangen
dc.contributor.authorLin, Wenhanen
dc.contributor.authorQian, Pei-Yuanen
dc.date.accessioned2014-08-27T09:48:54Z-
dc.date.available2014-08-27T09:48:54Z-
dc.date.issued2012-02-03en
dc.identifier.citationLi Y, Xu Y, Liu L, Han Z, Lai PY, et al. (2012) Five New Amicoumacins Isolated from a Marine-Derived Bacterium Bacillus subtilis. Marine Drugs 10: 319-328. doi:10.3390/md10020319.en
dc.identifier.issn16603397en
dc.identifier.pmid22412803en
dc.identifier.doi10.3390/md10020319en
dc.identifier.urihttp://hdl.handle.net/10754/325356en
dc.description.abstractFour novel amicoumacins, namely lipoamicoumacins A-D (1-4), and one new bacilosarcin analog (5) were isolated from culture broth of a marine-derived bacterium Bacillus subtilis, together with six known amicoumacins. Their structures were elucidated on the basis of extensive spectroscopic (2D NNR, IR, CD and MS) analysis and in comparison with data in literature. 2012 by the authors; licensee MDPI.en
dc.language.isoenen
dc.publisherMDPI AGen
dc.rightsThis article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).en
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en
dc.subjectAntibacterialen
dc.subjectBacillus subtilisen
dc.subjectCytotoxicityen
dc.subjectLipoamicoumacinen
dc.subjectamicoumacin aen
dc.subjectantiinfective agenten
dc.subjectbacilosarcin ben
dc.subjectbacilosarcin cen
dc.subjectlipoamicoumacin aen
dc.subjectlipoamicoumacin ben
dc.subjectlipoamicoumacin cen
dc.subjectlipoamicoumacin den
dc.subjectlipoamicoumacin derivativeen
dc.subjectnatural producten
dc.subjectunclassified drugen
dc.subjectanalytic methoden
dc.subjectantibacterial activityen
dc.subjectantineoplastic activityen
dc.subjectbacterial strainen
dc.subjectbacteriumen
dc.subjectcancer cell cultureen
dc.subjectcarbon nuclear magnetic resonanceen
dc.subjectChromobacterium violaceumen
dc.subjectcircular dichroismen
dc.subjectcontrolled studyen
dc.subjectcytotoxicityen
dc.subjectdrug isolationen
dc.subjectdrug structureen
dc.subjectdrug synthesisen
dc.subjectelectrospray mass spectrometryen
dc.subjectfermentationen
dc.subjecthuman cellen
dc.subjectIC 50en
dc.subjectinfrared spectroscopyen
dc.subjectLoktanella hongkongensisen
dc.subjectmarine bacteriumen
dc.subjectminimum inhibitory concentrationen
dc.subjectnucleotide sequenceen
dc.subjectproton nuclear magnetic resonanceen
dc.subjectPseudomonas aeruginosaen
dc.subjectseparation techniqueen
dc.subjectStaphylococcus aureusen
dc.subjectstructure analysisen
dc.subjecttwo dimensional electrophoresisen
dc.subjectuterine cervix carcinomaen
dc.subjectAnti-Bacterial Agentsen
dc.subjectAquatic Organismsen
dc.subjectCoumarinsen
dc.subjectDrug Discoveryen
dc.subjectFermentationen
dc.subjectGram-Negative Bacteriaen
dc.subjectGram-Positive Bacteriaen
dc.subjectHeLa Cellsen
dc.subjectIndian Oceanen
dc.subjectInhibitory Concentration 50en
dc.subjectMicrobial Sensitivity Testsen
dc.subjectMolecular Structureen
dc.subjectProteobacteriaen
dc.subjectStructure-Activity Relationshipen
dc.subjectThioctic Aciden
dc.subjectBacteria (microorganisms)en
dc.titleFive new amicoumacins isolated from a marine-derived Bacterium bacillus subtilisen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentKAUST Global Collaborative Research Programen
dc.contributor.departmentAdvanced Nanofabrication, Imaging and Characterization Core Laben
dc.identifier.journalMarine Drugsen
dc.identifier.pmcidPMC3296999en
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionState Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, Chinaen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorZhang, Xixiangen
kaust.authorGuo, Xiangrongen

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