Analysis of the distribution of magnetic fluid inside tumors by a giant magnetoresistance probe

Handle URI:
http://hdl.handle.net/10754/325329
Title:
Analysis of the distribution of magnetic fluid inside tumors by a giant magnetoresistance probe
Authors:
Gooneratne, Chinthaka P.; Kurnicki, Adam; Yamada, Sotoshi; Mukhopadhyay, Subhas C.; Kosel, Jürgen ( 0000-0002-8998-8275 )
Abstract:
Magnetic fluid hyperthermia (MFH) therapy uses the magnetic component of electromagnetic fields in the radiofrequency spectrum to couple energy to magnetic nanoparticles inside tumors. In MFH therapy, magnetic fluid is injected into tumors and an alternating current (AC) magnetic flux is applied to heat the magnetic fluid- filled tumor. If the temperature can be maintained at the therapeutic threshold of 42C for 30 minutes or more, the tumor cells can be destroyed. Analyzing the distribution of the magnetic fluid injected into tumors prior to the heating step in MFH therapy is an essential criterion for homogenous heating of tumors, since a decision can then be taken on the strength and localization of the applied external AC magnetic flux density needed to destroy the tumor without affecting healthy cells. This paper proposes a methodology for analyzing the distribution of magnetic fluid in a tumor by a specifically designed giant magnetoresistance (GMR) probe prior to MFH heat treatment. Experimental results analyzing the distribution of magnetic fluid suggest that different magnetic fluid weight densities could be estimated inside a single tumor by the GMR probe. 2013 Gooneratne et al.
KAUST Department:
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Citation:
Gooneratne CP, Kurnicki A, Yamada S, Mukhopadhyay SC, Kosel J (2013) Analysis of the Distribution of Magnetic Fluid inside Tumors by a Giant Magnetoresistance Probe. PLoS ONE 8: e81227. doi:10.1371/journal.pone.0081227.
Publisher:
Public Library of Science (PLoS)
Journal:
PLoS ONE
Issue Date:
29-Nov-2013
DOI:
10.1371/journal.pone.0081227
PubMed ID:
24312280
PubMed Central ID:
PMC3843682
Type:
Article
ISSN:
19326203
Appears in Collections:
Articles; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorGooneratne, Chinthaka P.en
dc.contributor.authorKurnicki, Adamen
dc.contributor.authorYamada, Sotoshien
dc.contributor.authorMukhopadhyay, Subhas C.en
dc.contributor.authorKosel, Jürgenen
dc.date.accessioned2014-08-27T09:47:14Zen
dc.date.available2014-08-27T09:47:14Zen
dc.date.issued2013-11-29en
dc.identifier.citationGooneratne CP, Kurnicki A, Yamada S, Mukhopadhyay SC, Kosel J (2013) Analysis of the Distribution of Magnetic Fluid inside Tumors by a Giant Magnetoresistance Probe. PLoS ONE 8: e81227. doi:10.1371/journal.pone.0081227.en
dc.identifier.issn19326203en
dc.identifier.pmid24312280en
dc.identifier.doi10.1371/journal.pone.0081227en
dc.identifier.urihttp://hdl.handle.net/10754/325329en
dc.description.abstractMagnetic fluid hyperthermia (MFH) therapy uses the magnetic component of electromagnetic fields in the radiofrequency spectrum to couple energy to magnetic nanoparticles inside tumors. In MFH therapy, magnetic fluid is injected into tumors and an alternating current (AC) magnetic flux is applied to heat the magnetic fluid- filled tumor. If the temperature can be maintained at the therapeutic threshold of 42C for 30 minutes or more, the tumor cells can be destroyed. Analyzing the distribution of the magnetic fluid injected into tumors prior to the heating step in MFH therapy is an essential criterion for homogenous heating of tumors, since a decision can then be taken on the strength and localization of the applied external AC magnetic flux density needed to destroy the tumor without affecting healthy cells. This paper proposes a methodology for analyzing the distribution of magnetic fluid in a tumor by a specifically designed giant magnetoresistance (GMR) probe prior to MFH heat treatment. Experimental results analyzing the distribution of magnetic fluid suggest that different magnetic fluid weight densities could be estimated inside a single tumor by the GMR probe. 2013 Gooneratne et al.en
dc.language.isoenen
dc.publisherPublic Library of Science (PLoS)en
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en
dc.subjectferucarbotranen
dc.subjectmagnetic fluiden
dc.subjectmagnetic nanoparticleen
dc.subjectunclassified drugen
dc.subjectalternating currenten
dc.subjectcell specificityen
dc.subjectdensityen
dc.subjectfinite element analysisen
dc.subjectgiant magnetoresistance probeen
dc.subjecthyperthermic therapyen
dc.subjectmagnetic fielden
dc.subjectmagnetic fluid hyperthermia therapyen
dc.subjectmechanical probeen
dc.subjectstatistical modelen
dc.subjecttissue distributionen
dc.subjecttumor cell destructionen
dc.titleAnalysis of the distribution of magnetic fluid inside tumors by a giant magnetoresistance probeen
dc.typeArticleen
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.identifier.journalPLoS ONEen
dc.identifier.pmcidPMC3843682en
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionAutomation and Metrology Department, Lublin University of Technology, Lublin, Polanden
dc.contributor.institutionInstitute of Nature and Environmental Technology, Kanazawa University, Kanazawa, Ishikawa, Japanen
dc.contributor.institutionSchool of Engineering and Advanced Technology, Massey University, Palmerston North, Manawatu, New Zealanden
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorGooneratne, Chinthaka Pasanen
kaust.authorKosel, Jürgenen

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