Magnetic Carbon Nanotubes as a Theranostic Platform for Drug Delivery and Magnetic Resonance Imaging

Handle URI:
http://hdl.handle.net/10754/322736
Title:
Magnetic Carbon Nanotubes as a Theranostic Platform for Drug Delivery and Magnetic Resonance Imaging
Authors:
Alkattan, Nedah
Abstract:
Carbon nanotubes (CNTs) have special characteristics that made them good agents especially for biomedical applications. In this study, Fe3O4 nanoparticles were incorporated onto the surface of CNTs followed by polyethylene glycol (PEG) grafting forming CNTs-Fe3O4-PEG hybrids. The PEGylation improves their biocompatibility, water solubility, and increases blood circulation. CNTs-Fe3O4-PEG was used as T2-contrat agent for magnetic resonance imaging (MRI). In addition, doxorubicin (DOX) was loaded onto CNTs-Fe3O4-PEG. The release of DOX from DOX-loaded CNTs-Fe3O4-PEG was tested under different pH conditions (7.4, 6.3 and 5.2). The release increased at acidic pH compared to neutral pH, which shows the sensitivity of the system to pH change. Triggering the release by Near Infra-Red (NIR) irradiation was furthermore investigated. The release increased after irradiation with NIR compared to control sample. These result prove that the designed system can be triggered by an internal stimuli (pH) and external stimuli (NIR irradiation) making it a promising candidate to be used for biomedical applications.
Advisors:
Khashab, Niveen M.
Committee Member:
Mohammed, Omar F. ( 0000-0001-8500-1130 ) ; Takanabe, Kazuhiro ( 0000-0001-5374-9451 )
KAUST Department:
Physical Sciences and Engineering (PSE) Division
Program:
Chemical Sciences
Issue Date:
Jun-2014
Type:
Thesis
Appears in Collections:
Theses; Physical Sciences and Engineering (PSE) Division; Chemical Science Program

Full metadata record

DC FieldValue Language
dc.contributor.advisorKhashab, Niveen M.en
dc.contributor.authorAlkattan, Nedahen
dc.date.accessioned2014-07-10T08:32:22Zen
dc.date.available2014-07-10T08:32:22Zen
dc.date.issued2014-06en
dc.identifier.urihttp://hdl.handle.net/10754/322736en
dc.description.abstractCarbon nanotubes (CNTs) have special characteristics that made them good agents especially for biomedical applications. In this study, Fe3O4 nanoparticles were incorporated onto the surface of CNTs followed by polyethylene glycol (PEG) grafting forming CNTs-Fe3O4-PEG hybrids. The PEGylation improves their biocompatibility, water solubility, and increases blood circulation. CNTs-Fe3O4-PEG was used as T2-contrat agent for magnetic resonance imaging (MRI). In addition, doxorubicin (DOX) was loaded onto CNTs-Fe3O4-PEG. The release of DOX from DOX-loaded CNTs-Fe3O4-PEG was tested under different pH conditions (7.4, 6.3 and 5.2). The release increased at acidic pH compared to neutral pH, which shows the sensitivity of the system to pH change. Triggering the release by Near Infra-Red (NIR) irradiation was furthermore investigated. The release increased after irradiation with NIR compared to control sample. These result prove that the designed system can be triggered by an internal stimuli (pH) and external stimuli (NIR irradiation) making it a promising candidate to be used for biomedical applications.en
dc.language.isoenen
dc.subjectCarbon nanotubesen
dc.subjectmagnetic Particlesen
dc.subjectMagnetic Resonance Imagingen
dc.subjectDrug Deliveryen
dc.subjectNear-infrared (NIR)en
dc.titleMagnetic Carbon Nanotubes as a Theranostic Platform for Drug Delivery and Magnetic Resonance Imagingen
dc.typeThesisen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
thesis.degree.grantorKing Abdullah University of Science and Technologyen_GB
dc.contributor.committeememberMohammed, Omar F.en
dc.contributor.committeememberTakanabe, Kazuhiroen
thesis.degree.disciplineChemical Sciencesen
thesis.degree.nameMaster of Scienceen
dc.person.id123612en
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