Prototyping chips in minutes: Direct Laser Plotting (DLP) of functional microfluidic structures

Handle URI:
http://hdl.handle.net/10754/303151
Title:
Prototyping chips in minutes: Direct Laser Plotting (DLP) of functional microfluidic structures
Authors:
Wang, Limu; Kodzius, Rimantas ( 0000-0001-9417-8894 ) ; Yi, Xin; Li, Shunbo; Hui, Yu Sanna; Wen, Weijia
Abstract:
We report a fast and simple prototyping method to fabricate polymer-based microfluidic chips using Direct Laser Plotting (DLP) technique, by which various functional micro-structures can be realized within minutes, in a mask-free and out-of-cleanroom fashion. A 2D Computer-Aid-Design (CAD) software was employed to layout the required micro-structures and micro-channels, a CO2 laser plotter was then used to construct the microstructures. The desired patterns can be plotted directly on PDMS substrates and bio-compatible polymer films by manipulating the strength and density of laser pulses. With the DLP technique, chip-embedded micro-electrodes, micro-mixers and 3D microfluidic chips with 5 layers, which normally require several days of work in a cleanroom facility, can be fabricated in minutes in common laboratory. This novel method can produce microfluidic channels with average feature size of 100 μm, while feature size of 50 μm or smaller is achievable by making use of the interference effect from laser impulsion. In this report, we present the optimized parameters for successful fabrication of 3D microchannels, micro-mixers and microfluidic chips for protein concentration measurements (Bovine Serum Albumine (BSA) test), and a novel procedure to pattern flexible embedding electrodes on PDMS-based microfluidic chips. DLP offers a convenient and low cost alternative to conventional microfluidic channel fabrication technique which relies on complicated and hazardous soft lithography process.
KAUST Department:
Computational Bioscience Research Center (CBRC)
Citation:
Wang L, Kodzius R, Yi X, Li S, Hui YS, et al. (2012) Prototyping chips in minutes: Direct Laser Plotting (DLP) of functional microfluidic structures. Sensors and Actuators B: Chemical 168: 214-222. doi:10.1016/j.snb.2012.04.011.
Publisher:
Elsevier BV
Journal:
Sensors and Actuators B: Chemical
Issue Date:
10-Oct-2013
DOI:
10.1016/j.snb.2012.04.011
Type:
Article
ISSN:
09254005
Sponsors:
Award No. SA-C0040/UK-C0016, made by King Abdullah University of Science and Technology (KAUST); Hong Kong RGC grants HKUST 603608 and 604710
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S0925400512003607
Appears in Collections:
Articles; Computational Bioscience Research Center (CBRC)

Full metadata record

DC FieldValue Language
dc.contributor.authorWang, Limuen
dc.contributor.authorKodzius, Rimantasen
dc.contributor.authorYi, Xinen
dc.contributor.authorLi, Shunboen
dc.contributor.authorHui, Yu Sannaen
dc.contributor.authorWen, Weijiaen
dc.date.accessioned2013-10-10T08:48:13Z-
dc.date.available2013-10-10T08:48:13Z-
dc.date.issued2013-10-10en
dc.identifier.citationWang L, Kodzius R, Yi X, Li S, Hui YS, et al. (2012) Prototyping chips in minutes: Direct Laser Plotting (DLP) of functional microfluidic structures. Sensors and Actuators B: Chemical 168: 214-222. doi:10.1016/j.snb.2012.04.011.en
dc.identifier.issn09254005en
dc.identifier.doi10.1016/j.snb.2012.04.011en
dc.identifier.urihttp://hdl.handle.net/10754/303151en
dc.description.abstractWe report a fast and simple prototyping method to fabricate polymer-based microfluidic chips using Direct Laser Plotting (DLP) technique, by which various functional micro-structures can be realized within minutes, in a mask-free and out-of-cleanroom fashion. A 2D Computer-Aid-Design (CAD) software was employed to layout the required micro-structures and micro-channels, a CO2 laser plotter was then used to construct the microstructures. The desired patterns can be plotted directly on PDMS substrates and bio-compatible polymer films by manipulating the strength and density of laser pulses. With the DLP technique, chip-embedded micro-electrodes, micro-mixers and 3D microfluidic chips with 5 layers, which normally require several days of work in a cleanroom facility, can be fabricated in minutes in common laboratory. This novel method can produce microfluidic channels with average feature size of 100 μm, while feature size of 50 μm or smaller is achievable by making use of the interference effect from laser impulsion. In this report, we present the optimized parameters for successful fabrication of 3D microchannels, micro-mixers and microfluidic chips for protein concentration measurements (Bovine Serum Albumine (BSA) test), and a novel procedure to pattern flexible embedding electrodes on PDMS-based microfluidic chips. DLP offers a convenient and low cost alternative to conventional microfluidic channel fabrication technique which relies on complicated and hazardous soft lithography process.en
dc.description.sponsorshipAward No. SA-C0040/UK-C0016, made by King Abdullah University of Science and Technology (KAUST); Hong Kong RGC grants HKUST 603608 and 604710en
dc.language.isoenen
dc.publisherElsevier BVen
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0925400512003607en
dc.rightsArchived with thanks to Sensors and Actuators B: Chemicalen
dc.subjectRapid chip prototypingen
dc.subjectDirect Laser Plottingen
dc.subjectPDMSen
dc.subjectMicrofluidicen
dc.subjectLab-On-a-Chip (LOC)en
dc.titlePrototyping chips in minutes: Direct Laser Plotting (DLP) of functional microfluidic structuresen
dc.typeArticleen
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.identifier.journalSensors and Actuators B: Chemicalen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionThe Hong Kong University of Science and Technology (HKUST)en
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorKodzius, Rimantasen
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